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Complement genes contribute sex-biased vulnerability in diverse disorders

researchsnappy by researchsnappy
May 13, 2020
in Healthcare Research
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  • 1.

    Ngo, S. T., Steyn, F. J. & McCombe, P. A. Gender differences in autoimmune disease. Front. Neuroendocrinol. 35, 347–369 (2014).

  • 2.

    Abel, K. M., Drake, R. & Goldstein, J. M. Sex differences in schizophrenia. Int. Rev. Psychiatry 22, 417–428 (2010).

  • 3.

    Langefeld, C. D. et al. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat. Commun. 8, 16021 (2017).

  • 4.

    Rioux, J. D. et al. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc. Natl Acad. Sci. USA 106, 18680–18685 (2009).

  • 5.

    Hanscombe, K. B. et al. Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans. Hum. Mol. Genet. 27, 3813–3824 (2018).

  • 6.

    Cruz-Tapias, P., Rojas-Villarraga, A., Maier-Moore, S. & Anaya, J. M. HLA and Sjögren’s syndrome susceptibility. a meta-analysis of worldwide studies. Autoimmun. Rev. 11, 281–287 (2012).

  • 7.

    Sekar, A. et al. Schizophrenia risk from complex variation of complement component 4. Nature 530, 177–183 (2016).

  • 8.

    Gaya da Costa, M. et al. Age and sex-associated changes of complement activity and complement levels in a healthy Caucasian population. Front. Immunol. 9, 2664 (2018).

  • 9.

    Ritchie, R. F. et al. Reference distributions for complement proteins C3 and C4: a practical, simple and clinically relevant approach in a large cohort. J. Clin. Lab. Anal. 18, 1–8 (2004).

  • 10.

    Lawrence, J. S., Martins, C. L. & Drake, G. L. A family survey of lupus erythematosus. 1. Heritability. J. Rheumatol. 14, 913–921 (1987).

  • 11.

    Lipsky, P. E. Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat. Immunol. 2, 764–766 (2001).

  • 12.

    Ippolito, A. et al. Autoantibodies in systemic lupus erythematosus: comparison of historical and current assessment of seropositivity. Lupus 20, 250–255 (2011).

  • 13.

    Lee, K. H., Wucherpfennig, K. W. & Wiley, D. C. Structure of a human insulin peptide–HLA–DQ8 complex and susceptibility to type 1 diabetes. Nat. Immunol. 2, 501–507 (2001).

  • 14.

    Raychaudhuri, S. et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat. Genet. 44, 291–296 (2012).

  • 15.

    Morris, D. L. et al. MHC associations with clinical and autoantibody manifestations in European SLE. Genes Immun. 15, 210–217 (2014).

  • 16.

    Bánlaki, Z., Doleschall, M., Rajczy, K., Fust, G. & Szilágyi, A. Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes. Genes Immun. 13, 530–535 (2012).

  • 17.

    Isenman, D. E. & Young, J. R. The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4. J. Immunol. 132, 3019–3027 (1984).

  • 18.

    Law, S. K., Dodds, A. W. & Porter, R. R. A comparison of the properties of two classes, C4A and C4B, of the human complement component C4. EMBO J. 3, 1819–1823 (1984).

  • 19.

    Birmingham, D. J. et al. The complex nature of serum C3 and C4 as biomarkers of lupus renal flare. Lupus 19, 1272–1280 (2010).

  • 20.

    Ross, S. C. & Densen, P. Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency. Medicine 63, 243–273 (1984).

  • 21.

    Wu, Y. L., Hauptmann, G., Viguier, M. & Yu, C. Y. Molecular basis of complete complement C4 deficiency in two North-African families with systemic lupus erythematosus. Genes Immun. 10, 433–445 (2009).

  • 22.

    International Consortium for Systemic Lupus Erythematosus. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat. Genet. 40, 204–210 (2008).

  • 23.

    Yang, Y. et al. Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. Am. J. Hum. Genet. 80, 1037–1054 (2007).

  • 24.

    Jüptner, M. et al. Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus. Lupus 27, 600–609 (2018).

  • 25.

    Boteva, L. et al. Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations. Am. J. Hum. Genet. 90, 445–456 (2012).

  • 26.

    Pato, M. T. et al. The genomic psychiatry cohort: partners in discovery. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 162, 306–312 (2013).

  • 27.

    Sanders, S. J. et al. Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nat. Neurosci. 20, 1661–1668 (2017).

  • 28.

    Kuo, C. F. et al. Familial risk of Sjögren’s syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study. Arthritis Rheumatol. 67, 1904–1912 (2015).

  • 29.

    Fayyaz, A., Kurien, B. T. & Scofield, R. H. Autoantibodies in Sjögren’s Syndrome. Rheum. Dis. Clin. North Am. 42, 419–434 (2016).

  • 30.

    Ramos-Casals, M. et al. Hypocomplementaemia as an immunological marker of morbidity and mortality in patients with primary Sjögren’s syndrome. Rheumatology 44, 89–94 (2005).

  • 31.

    Chused, T. M., Kassan, S. S., Opelz, G., Moutsopoulos, H. M. & Terasaki, P. I. Sjögren’s syndrome association with HLA-Dw3. N. Engl. J. Med. 296, 895–897 (1977).

  • 32.

    Taylor, K. E. et al. Genome-wide association analysis reveals genetic heterogeneity of Sjögren’s syndrome according to ancestry. Arthritis Rheumatol. 69, 1294–1305 (2017).

  • 33.

    Khramtsova, E. A., Davis, L. K. & Stranger, B. E. The role of sex in the genomics of human complex traits. Nat. Rev. Genet. 20, 173–190 (2019).

  • 34.

    Hughes, T. et al. Analysis of autosomal genes reveals gene–sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann. Rheum. Dis. 71, 694–699 (2012).

  • 35.

    GTEx Consortium. Genetic effects on gene expression across human tissues. Nature 550, 204–213 (2017).

  • 36.

    Brinks, R. et al. Age-specific and sex-specific incidence of systemic lupus erythematosus: an estimate from cross-sectional claims data of 2.3 million people in the German statutory health insurance 2002. Lupus Sci. Med. 3, e000181 (2016).

  • 37.

    Kim, H. J. et al. Incidence, mortality, and causes of death in physician-diagnosed primary Sjögren’s syndrome in Korea: A nationwide, population-based study. Semin. Arthritis Rheum. 47, 222–227 (2017).

  • 38.

    Degn, S. E. et al. Clonal evolution of autoreactive germinal centers. Cell 170, 913–926 (2017).

  • 39.

    Estrada, K. et al. A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica. Nat. Commun. 9, 1929 (2018).

  • 40.

    Pittock, S. J. et al. Neuromyelitis optica and non organ-specific autoimmunity. Arch. Neurol. 65, 78–83 (2008).

  • 41.

    Erdei, A. et al. Expression and role of CR1 and CR2 on B and T lymphocytes under physiological and autoimmune conditions. Mol. Immunol. 46, 2767–2773 (2009).

  • 42.

    Unterman, A. et al. Neuropsychiatric syndromes in systemic lupus erythematosus: a meta-analysis. Semin. Arthritis Rheum. 41, 1–11 (2011).

  • 43.

    Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014).

  • 44.

    Handsaker, R. E. et al. Large multiallelic copy number variations in humans. Nat. Genet. 47, 296–303 (2015).

  • 45.

    Browning, S. R. & Browning, B. L. Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Am. J. Hum. Genet. 81, 1084–1097 (2007).

  • 46.

    Browning, B. L. & Browning, S. R. Genotype imputation with millions of reference samples. Am. J. Hum. Genet. 98, 116–126 (2016).

  • 47.

    Zheng, X. et al. HIBAG—HLA genotype imputation with attribute bagging. Pharmacogenomics J. 14, 192–200 (2014).

  • 48.

    Zheng, X. Imputation-based HLA typing with SNPs in GWAS studies. Methods Mol. Biol. 1802, 163–176 (2018).

  • 49.

    Luykx, J. J. et al. A common variant in ERBB4 regulates GABA concentrations in human cerebrospinal fluid. Neuropsychopharmacology 37, 2088–2092 (2012).

  • 50.

    Albersen, M. et al. Vitamin B-6 vitamers in human plasma and cerebrospinal fluid. Am. J. Clin. Nutr. 100, 587–592 (2014).

  • 51.

    Malladi, A. S. et al. Primary Sjögren’s syndrome as a systemic disease: a study of participants enrolled in an international Sjögren’s syndrome registry. Arthritis Care Res. (Hoboken) 64, 911–918 (2012).

  • 52.

    The ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57–74 (2012).

  • 53.

    Kent, W. J. et al. The human genome browser at UCSC. Genome Res. 12, 996–1006 (2002).

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