Research Snappy
  • Market Research Forum
  • Investment Research
  • Consumer Research
  • More
    • Advertising Research
    • Healthcare Research
    • Data Analysis
    • Top Companies
    • Latest News
No Result
View All Result
Research Snappy
No Result
View All Result

Gestational diabetes exposure tied to higher cholesterol, BP in children

researchsnappy by researchsnappy
January 15, 2020
in Healthcare Research
0
Gestational diabetes exposure tied to higher cholesterol, BP in children
399
SHARES
2.3k
VIEWS
Share on FacebookShare on Twitter

Exposure to gestational diabetes in utero is associated with worse cardiovascular health in offspring from childhood through adolescence, according to an analysis of health plan data published in Pediatric Obesity.

“The prevention of maternal gestational diabetes can improve offspring cardiovascular outcomes,” Wei Perng, MPH, PhD, assistant professor of epidemiology and assistant director of the Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center at the Colorado School of Public Health, University of Colorado Denver Anschutz Medical Campus, told Healio. “It is important to identify viable and effective methods of preventing gestational diabetes. This has proved challenging, and it is likely that a more nuanced understanding of mechanisms linking maternal gestational diabetes to poor cardiovascular outcomes in offspring is needed.”

Perng and colleagues analyzed data from 597 youths with at least one CV risk factor of interest whose mothers were members of the Kaiser Permanente of Colorado health plan (50% girls; 48.1% white). Within the cohort, 92 mothers had a diagnosis of gestational diabetes. Researchers used mixed-effects linear regression models to examine associations of maternal gestational diabetes with average offspring levels of serum lipids (total cholesterol, HDL and LDL cholesterol, and triglycerides) and systolic blood pressure across two research visits (mean age at visits, 11 and 17 years; mean follow-up time, 6 years). In sex-stratified analyses, researchers also evaluated the influence of sociodemographic characteristics, pubertal status, physical activity and total energy intake, maternal BMI, gestational diabetes treatment and offspring BMI.

Gestational diabetes 2019 

Exposure to gestational diabetes in utero is associated with worse cardiovascular health in offspring from childhood through adolescence.

Source: Adobe Stock

Compared with unexposed girls, gestational diabetes exposure was associated with higher total cholesterol (mean, 0.38 mmol/L; 95% CI, 0.16-0.61) and higher LDL cholesterol (mean, 0.34 mmol/L; 95% CI, 0.14-0.53) among girls. Adjustment for gestational diabetes treatment attenuated both estimates by approximately two-thirds the magnitude, according to researchers.

Among boys, exposure to gestational diabetes was associated with an average 4.5 mm Hg higher systolic BP compared with boys not exposed to gestational diabetes (95% CI, 1.9-7.1), with results persisting after adjustment for sociodemographic and lifestyle factors, maternal BMI, and gestational diabetes treatment. The association for boys was attenuated by approximately 30% after adjusting for current BMI, according to researchers.

“In girls, gestational diabetes was associated with higher total cholesterol and LDL [cholesterol],” the researchers wrote. “In boys, gestational diabetes corresponded with consistently higher systolic BP. These associations were consistent across the age-range studied and did not change over time.”

The researchers noted that the effect sizes detected are modest; however, they may have important long-term ramifications given that cardiometabolic risk factors track from childhood into adulthood and are independent predictors of CV risk. – by Regina Schaffer

For more information:

Wei Perng, MPH, PhD, can be reached at Colorado School of Public Health, University of Colorado Denver, Anschutz Medical Campus, 12474 E. 19th Ave., Room 208, Aurora, CO 80045; email: [email protected].

Disclosures: The authors report no relevant financial disclosures.

Previous Post

Goldman Sachs Q4 profit falls, but sees higher bond trading, deal-making

Next Post

IPA Bellwether Report Q4 2019: Return to Marketing Budget Growth

Next Post
IPA Bellwether Report Q4 2019: Return to Marketing Budget Growth

IPA Bellwether Report Q4 2019: Return to Marketing Budget Growth

Research Snappy

Category

  • Advertising Research
  • Consumer Research
  • Data Analysis
  • Healthcare Research
  • Investment Research
  • News

Pa. Republicans reconsider Pitt funding over fetal tissue research, college voucher program

Arthur Pharma Closes Series A Financing Round

YouTube and the Achilles Tendon: An Analysis of Internet Information Reliability and Content Quality

  • Privacy Policy
  • Terms of Use
  • Antispam
  • DMCA
  • Contact Us

© 2022 researchsnappy.com

No Result
View All Result
  • Market Research Forum
  • Investment Research
  • Consumer Research
  • More
    • Advertising Research
    • Healthcare Research
    • Data Analysis
    • Top Companies
    • Latest News

© 2022 researchsnappy.com