Exome Capture Kit
ExomeCG is a clinically enhanced exome capture kit that—for the first time—allows confident, robust whole-exome sequencing and targeted copy number analysis in a single assay. The clinically validated test replaces the need for chromosomal microarray and multiplex ligation-dependent probe amplification (MLPA) front line tests, saving time and money while achieving the highest diagnostic yield possible. ExomeCG is designed to provide unparalleled coverage of clinical targets when used in combination with the Congenica clinical decision support platform, which enables fast, accurate interpretation of next-generation sequencing data for health care professionals, helping them to deliver world-class genomic medicine services and make important clinical decisions.
Touchscreen Motorized Repeating Pipette
The BRAND HandyStep touch motorized repeating pipette features a touchscreen interface for intuitive operation. The large color display provides all pertinent information and allows easy adjustment of all parameters. It can be used with all standard repeating pipette tips. Automatic size recognition of BRAND PD-Tip II precision dispenser tips adds to the ease of use and reduces the chance of errors. Two models are available: The HandyStep touch features dispensing, auto-dispensing, and single-volume pipetting modes, with the ability to save up to 10 favorites. The auto-dispensing mode features a “learn” function for easy interval programming. The HandyStep touch S adds multiaspiration, sequential dispensing, and titration modes.
mRNA Transfection Reagent
Polyplus-transfection announces the launch of in vivo-jetRNA, an injectable messenger RNA (mRNA) transfection reagent. Addition-ally, its adaptability enables multiple administration routes to target an organ of choice in all types of animals—especially the spleen and lymphatic nodes that play a major role in vaccination. As plasmid DNA, mRNA can be used to transiently express a specific antigen into an organism or tissue. This antigen will be recognized by the immune system through antigen-presenting cells and triggers a specific immune response. It is also beneficial for cancer research, as it can be used to express a suicide gene to kill cancer cells.
Abcam’s new engineered knockout (KO) cell lysates enable proteomic studies by providing researchers with true negative controls. Acquiring reliable, off-the-shelf KO mouse models or cell lines that match specific experimental requirements can be challenging; these often need to be sourced directly from individual researchers or labs. Abcam’s newly launched collection addresses this issue by providing access to over 2,800 diploid KO cell lysates. These lysates are useful for studies requiring loss-of-function phenotypes at the proteomic level as well as routine applications such as Western blotting and mass spectroscopy. They can also be used to support antibody and target validation. The use of diploid cells makes them well suited to the more complex studies often carried out in cancer research. Derived from commonly used immortalized cell lines, KO lysates have been engineered using CRISPR-Cas9 and are accompanied by Sanger sequencing and Western blotting validation data. Corresponding wild-type controls are also provided so that the biological impact of each KO lysate can easily be assessed within a consistent cellular background.
Protein Extraction Kit
The Chromatrap Protein Extraction kit from Porvair Sciences offers a fast, efficient method of extracting cytoplasmic, nuclear, or total protein from mammalian cells. Combining the optimized protocol with proprietary reagents, the kit provides high yields of purified active protein with low cross-fraction contamination in less than 90 min. It is easy to use, avoiding the need for ultracentrifugation steps and delivering reproducible preparation of purified protein extracts from a wide variety of biological samples. Affordably priced, the kit generates high-quality protein samples that may be directly applied to several applications, including Western blotting, gel-shift assays, protein assays, reporter gene assays, and enzyme activity assays.
Automated Perfusion Cell Culture System
The Corning MicroDEN is an automated perfusion cell culture system that provides a more efficient process for the differentiation of monocytes into dendritic cells than current manual methods. It enables the wide use of dendritic cells in cell and gene therapy for basic and applied research in immunology and immuno-oncology. Developed by Flaskworks, a Boston-based startup company specializing in technologies for therapeutic cell production, MicroDEN is now available from Corning. The rise of personalized immunotherapies has increased demand for dendritic cells. However, the current process for generating these cells is cumbersome, error prone, and time intensive. Dendritic cells are key elements in immunology and immunotherapy research in oncology and infectious diseases as well as autoimmune diseases and transplant rejection. MicroDEN stream-lines the process by minimizing manual steps, resulting in more consistent yields, reduced risk of contamination, and more efficient therapy research.
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