Research Snappy
  • Market Research Forum
  • Investment Research
  • Consumer Research
  • More
    • Advertising Research
    • Healthcare Research
    • Data Analysis
    • Top Companies
    • Latest News
No Result
View All Result
Research Snappy
No Result
View All Result

Inflammatory Response to Stress May Predict CBT Response in Youth With Mood Disorders

researchsnappy by researchsnappy
November 18, 2019
in Healthcare Research
0
Inflammatory Response to Stress May Predict CBT Response in Youth With Mood Disorders
400
SHARES
2.4k
VIEWS
Share on FacebookShare on Twitter

Study data published in the Journal of Psychiatry Research found modest correlations between immune response to stress and cognitive behavioral therapy (CBT) outcomes in adolescents with mood disorders.

Jennifer G Pearlstein, of the University of California Berkeley, led a preliminary pilot study to assess the feasibility of using inflammation markers to predict CBT response.

Adolescents with a primary mood disorder diagnosis were recruited from the Division of Child and Adolescent Psychiatry at the Stanford University School of Medicine. Eligible diagnoses included major depressive disorder and bipolar disorder types I, II, or not otherwise specified.

Enrollees participated in a 10-session, 90-minute per week CBT group. Pre and post-group assessments were administered at weeks 1 and 10, respectively, and included stress induction using the Trier Social Stress Test (TSST). Blood samples were taken before the TSST and at 30, 60, and 90 minutes post-TSST and then analyzed for cytokine levels. Hierarchic linear models were conducted for the baseline and follow-up laboratory sessions to assess changes in inflammatory cytokines over time. The area under the curve with respect to increase (AUCi) was calculated for each cytokine; linear regression models using AUCi were performed to predict depressive symptoms at follow-up.

Among 34 adolescents who completed pre- and post- group assessments, 28 had valid cytokine data (mean age, 15.03±1.91 years; 41.2% boys). A significant reduction in depression symptoms as measured by the Children’s Depression Rating Scale was observed at follow-up (P <.05).

Results for the efficacy of cytokine markers were mixed. At baseline, a significant effect of time was observed only for interleukin (IL)-6 (P <.01). At the post-group assessment, a significant effect of time was observed for both IL-12 (P <.05) and IL-6 (P <.001). As such, IL-6 and IL-12 appeared to be sensitive to acute psychosocial stress in a laboratory setting.

At the pre-group assessment, the AUCi for tumor necrosis factor-α and IL-1β (both P <.05) was negatively associated with depressive symptoms. The AUCi for IL-1β was also inversely associated with life stress (P <.05). At follow-up, the AUCi for IL-6 and interferon (IFN)γ were positively associated with depressive symptoms and the AUCi for IL-8 was negatively associated with life stress (all P <.05). In models that predicted follow-up AUCi using baseline AUCi and chronic stress levels, there was a significant main effect of stress for IL-1β (P <.05) and a nominal effect of stress for IL-8 (P =.06) and IFNγ (P =.07). Linear regression markers using AUCi for each inflammatory marker showed mixed results. Models using IL-12 and IL-1β significantly predicted post-group depression symptoms (P <.05).

As study limitations, investigators cited the small study cohort and potential confounding effects of psychotropic medication use in patients. Additionally, cytokines were assessed separately, although inflammatory markers typically operate in tandem.

“Inflammatory response to stress induction is a feasible putative mechanism of change in CBT in youth,” authors wrote.

Reference

Pearlstein JG, Staudenmaier PJ, West AE, Geraghty S, Cosgrove VE. Immune response to stress induction as a predictor of cognitive-behavioral therapy outcomes in adolescent mood disorders: a pilot study. J Psychiatr Res. 2019;120:56-63.

Previous Post

Warren Buffett increases Apple stake despite selling some stock

Next Post

Tanvas Named a Cool Vendor in Display and Vision, 2019 by Gartner

Next Post
Tanvas Named a Cool Vendor in Display and Vision, 2019 by Gartner

Tanvas Named a Cool Vendor in Display and Vision, 2019 by Gartner

Research Snappy

Category

  • Advertising Research
  • Consumer Research
  • Data Analysis
  • Healthcare Research
  • Investment Research
  • News

Pa. Republicans reconsider Pitt funding over fetal tissue research, college voucher program

Arthur Pharma Closes Series A Financing Round

YouTube and the Achilles Tendon: An Analysis of Internet Information Reliability and Content Quality

  • Privacy Policy
  • Terms of Use
  • Antispam
  • DMCA
  • Contact Us

© 2022 researchsnappy.com

No Result
View All Result
  • Market Research Forum
  • Investment Research
  • Consumer Research
  • More
    • Advertising Research
    • Healthcare Research
    • Data Analysis
    • Top Companies
    • Latest News

© 2022 researchsnappy.com