The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment
INTRODUCTIONPoly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor important for maintaining genomic integrity. PARP1 recognizes and binds both single-strand breaks (SSBs) and double-strand breaks (DSBs), triggering its ADP-ribose polymerase...









