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Loss-of-function polymorphism in IL6R reduces risk of JAK2V617F somatic mutation and myeloproliferative neoplasm: A Mendelian randomization study

IntroductionPhiladelphia chromosome-negative myeloproliferative neoplasms (myeloproliferative neoplasm) comprises essential thrombocythaemia, polycythaemia vera, and myelofibrosis and are clonal stem cell neoplasms characterized by chronic inflammation, clonal myeloproliferation, and myelo-accumulation leading to elevated...

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