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To Sustain Future Growth, Drug Developers are Considering such Devices for Product Life Cycle Management and are Likely to Evaluate Novel Drug-Device Combinations

rootsanalysis — Wed, 15 Jul 2020 12:02:32 +0000

According to the Centers for Disease Control and Prevention, diabetes, migraine and cancer are responsible for 7 out of 10 deaths in the US. Further, as per the WHO, the prevalence of such chronic diseases is expected to reach 57% by 2020. On the treatment side, the rise in prevalence of such clinical conditions is expected to translate into an increase in the need for medications that are required to be administered frequently. For patients who need to medicate several times a day, self-administration is now a preferred option using devices, such as prefilled syringes, pen-injectors and autoinjectors.

Further, a number of biologics have received approval in the last decade. Owing to their large size and unstable nature, these drugs are usually formulated for parenteral delivery and prefilled syringes have become the primary container of choice for many such drugs / therapies, including monoclonal antibodies and vaccines. Some factors responsible for this preference include:

Most biologics require parenteral administration
Biologics are costlier than pharmaceutical drugs and packaging of biologics in prefilled syringes reduces overfills, saving costs
Prefilled syringes allow product differentiation
Ease of use and ability to save time helps to deploy vaccines in mass immunization programs
Ease of use allows self-administration of drugs for chronic conditions

As mentioned above, in addition to end-users, prefilled syringes also offer several advantages to manufacturers. It is worth highlighting that development of biologics in combination with prefilled syringes has garnered a lot of interest in the biopharma industry. However, some technical issues, such as functionality issues and syringe siliconization, are yet to be addressed to ensure better compatibility between the drug and the device.

In addition, the growth of prefilled syringes will also be impacted by the launch of biosimilars, since the expiry of patents of blockbuster mAbs is likely to be followed by the launch of biosimilar drugs. According to a study, as of February 2019, around 1,041 biosimilar molecules were being evaluated in clinical trials. Despite the fact that development of biosimilar requires huge money and time investment, the potential returns are enormous. As per a study conducted by GaBI, biologics with estimated revenues of over USD 68 billion have already lost patent protection. Further, biologics with estimated revenues of USD 100 billion are anticipated to lose patent exclusivity by 2020; this will lead to the expansion of the biosimilars market.

Over time, prefilled syringes have become indispensable to modern drug delivery practices. Moreover, their use as primary packaging for various other next generation therapeutic administration devices makes them an important lifecycle management tool as well. Examples of approved autoinjectors that use prefilled syringes as their primary container include (no selection criteria, in alphabetical order) Emgality prefilled pen (Eli Lilly), Nucala autoinjector (GSK), Vyleesi autoinjector (AMAG Pharmaceuticals / Palatin Technologies) and Xyosted autoinjector (Antares Pharma).

Moreover, our analysis has revealed nine approved products and 160 clinical drug candidates that are likely to be evaluated for delivery via prefilled syringes. It is worth mentioning that the abovementioned drugs / drug candidates are designed for the treatment of chronic conditions, require frequent dosing, and are not currently available in self-administration systems. We are led to believe that they are likely to soon be evaluated in different drug-device combinations.

Additionally, based on likely partner analysis, 61% companies are likely to be evaluated for partnership for development of prefilled syringe combination products. Majority (33) of these likely partners are headquartered in North America, followed by Europe. It is worth highlighting that, among Asia-Pacific and RoW based companies, BioLineRx, Genexine and Jiangsu HengRui Medicine are most likely to be evaluated for partnership for the development of prefilled syringe combination products.

Further, an analysis on top 20 big pharma players (based on the annual revenues) highlighted that Sanofi has the maximum number of approved and under development prefilled syringe combination products. On the other hand, Johnson & Johnson, with a strong pipeline of injectable drugs, across various therapeutic areas, has the maximum number of drugs that are likely to be developed in combination of prefilled syringes.

Furthermore, majority of the big pharma players have strong pipeline of injectables for treating autoimmune disorders. Within autoimmune disorders, Johnson & Johnson has maximum number of approved and under development prefilled syringe combination products. On the other hand, Amgen has higher likelihood of developing its pipeline drugs in combination with prefilled syringes.

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Shenzhen Jingbang Hardware Electronic Co., Ltd.

cyylyy2 — Mon, 24 Feb 2020 01:17:26 +0000

Shenzhen Jingbang Hardware Electronic Co., Ltd. was established 10 years ago. The main products: 3D printer parts,CNC plates(such as :v slot linear rail,slot v wheel,Customized CNC plates ,Aluminum spacer etc )with standard fasteners (such as the screws, bolts, nuts, washers and so on), non-standard fasteners, CNC machining parts, stamping parts, lathe parts, etc. The standard can be according to GB, DIN, ANSI, JIS, ISO, EN, JB, NFE and UNI standards.Jingbang have helped customers to design many new products and save cost. Product development can offer many business opportunities to customers. After so many years’ development, now we have many different kinds of patented products.
http://www.jingbang-3dparts.com/

top 10 digital marketing institutes in bangalore

maruthan — Mon, 27 Jan 2020 08:12:48 +0000

Traditional Marketing is getting dead with the rise of Internet technology and an increase in the involvement of internet devices in our day to day life. All the Modes of Traditional marketing (i.e. T.V, Newspaper, Radio, Banners) are slowly getting low effective in a mode of Interaction to the customer. As per the recent stats from IndiaTimes Indians spends 17 hours per week on Social Media which is a World Record. An Average person spends around 6 Hrs per day on the Internet through different devices (i.e. Mobile, Laptops, Tabs and Smartwatches), creating the best platform for companies to promote Digitally.

Bangalore the STARTUP CITY/ IT HUB/SILICON VALLEY/ of India, is filled with Start-Ups, Corporates, MNC’s and local Businesses. The Organizations/Businesses are looking for trained Digital Marketers who can maintain and grow their Brand Authority Online and Generate Leads/Revenue through reaching to the targeted audience.

There is a rapidly growing demand for well trained Digital Marketing Professionals.

In India, the gap between supply and demand for Digital Marketing Professionals has led to training institutions cropping up in several locations across the country. These Institutions offer Digital Marketing Courses and make aspirants industry ready by providing Industry grade training and assistance for a specific duration. If you’ve chosen Digital Marketing as your career path, you’ve certainly made an excellent decision but you’re yet to put your plan into motion. This is why you need a reputable Digital Marketing Training Institute in Bangalore to make your dream of being a Digital Marketing Professional come true.

Bengaluru is India’s Silicon Valley and it is only fitting that this city is the home to some of the top Digital Marketing Training Institutes. Bengaluru has no dearth of talented individuals who can achieve massive success in a career in Digital Marketing if they’re given the right guidance and training.

The best part is there is no academic qualification requirement or age limit for becoming a Certified Digital Marketer

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